The outcome of Cognitive Behavior Therapy (CBT) in respect to management of depression has been encouraging as revealed by various researchers. The present study attempts to highlight the role of CBT in the management of a 35 years old, male, owner of a travelling agency with depressive symptoms. He was treated with CBT approach. A single case design with pre-and post-therapy assessment was used. Hamilton Rating Scale for Depression (HAM-D) was used to assess the existence and severity of symptoms of depression. Significant improvement occurred after 10 sessions of cognitive behavioral interventions. Patient was found functioning normally after 6 months of follow-up. The findings of present study indicated the effectiveness of cognitive behavior therapy in treatment of depression.